Research Type: Extramural
By targeting the specific drivers of childhood brain cancers, this project aims to develop a safer and more effective approach to treating these children.
Associate Professor Clare Stirzaker and her team are developing an accurate and sensitive test that can detect breast cancer in blood, also known as a liquid biopsy.
Improving the precision of this novel radiation technology could present a new treatment strategy for the 1,200 Australians diagnosed with locally advanced pancreatic cancer each year.
In this project Professor Fazekas and team will analyse pre- and post-therapy blood samples from breast cancer patients and use machine learning statistical techniques to identify the immune signatures that can predict patient response to a particular therapy with the greatest accuracy.
Dr van Delft and Dr Lew co-lead a team with Dr White that aims to enhance the effectiveness of venetoclax, rendering resistant cancer cells sensitive to treatment.
The project aims to develop experimental research using the proposed hardware to show 3D imagining during treatment, MRI quality imaging during treatment and reconstructing actual delivered dose post treatment.
If successful, this project will generate clinically translatable approaches to enhance AML therapy ready for progression to clinical trials to improve outcomes for AML patients.
Professor Turner’s team aims to use cutting edge imaging approaches to shed light on how changes in nutrient metabolism and intracellular signalling contribute to two lethal characteristics of pancreatic cancer, namely chemoresistance and metastatic spread.
Dr Mithraprabhu and her team aims to overcome the challenges caused by the genetic complexity of multiple myeloma by using DNA obtained from the blood instead of a single-site bone marrow biopsy.
The team has developed a methodology to map the fibrotic tumour landscape, through real-time imaging of (i) the proximity of cancer cells to the host blood supply, (ii) their location with regards to the tumour invasive borders and (iii) the surrounding tissue compartment.