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      • View 45 other cancers
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      • Fatigue
      • Taste and smell changes
      • Heart health and cancer
      • Hair loss
      • Pain and cancer
      • Peripheral neuropathy
      • Changes in thinking and memory
      • Lymphoedema
      • Mouth health
      • Nutrition and cancer
      • Breast prostheses and reconstruction
      • Fertility
      • Sexuality
    • Supporting someone with cancer
      • Caring for someone with cancer
      • Caring for someone with advanced cancer
      • Family and friends
      • Supportive schools
      • Supportive workplaces
      • Caring for mob with cancer
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      • Nutrition and cancer
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    • 13 11 20 – Speak to a cancer professional
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      • Accommodation during treatment
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      • Coping with emotions
      • Talking to kids about cancer
      • Cancer and your finances
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    • Cancer stories
    • Cancer podcasts
    • Meditation and relaxation podcasts
  • Preventing Cancer
    Discover lifestyle choices to minimise your risk of getting cancer and the importance of screening and early detection for cancer survival.
    • Healthy diet and exercise
      • Limit alcohol
      • Be a healthy weight
      • Move more, sit less
      • Healthy Made Tasty
      • Our Kids Our Call
    • Quit smoking and vaping
      • Quit smoking
      • Tackling Tobacco
      • Smoke free environments
      • Electronic cigarettes
      • Generation Vape
    • Sun protection
      • Slip on a shirt
      • Slop on sunscreen
      • Slap on a hat
      • Seek shade
      • Slide on sunglasses
      • SunSmart NSW website
      • Improve your long game
      • Outdoor workers
      • Sporting groups
      • Buy sun protection products online
    • Screening and early detection
      • Cervical screening
      • Bowel cancer screening
      • Breast cancer screening
      • Lung cancer screening
      • Testicular cancer
      • Prostate cancer
      • Ovarian cancer
      • Liver cancer and hepatitis B
      • Check for skin cancer
    • CanAct – campaigning for better policies
    • Cancer Council shops
  • Research
    Research programs save lives, improve treatments and quality of life for cancer survivors.
    • Research we conduct
      • The Daffodil Centre
      • I-PaRCS
    • Research we fund
    • Search research by cancer type or topic
    • Information for researchers
      • Grant opportunities
    • Community participation in research
  • Get Involved
    Cancer Council exists through the generosity of the community. Find out how you can participate by donating, volunteering, fundraising or partnering with us.
    • Donate
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      • Donate in memory of a loved one
      • Make a major gift
      • Donate crypto
      • More ways to donate
    • Events and Fundraising
      • Events calendar
      • Fundraise your way – Do It For Cancer
      • Australia’s Biggest Morning Tea
      • Daffodil Day
      • Relay for Life
      • The Longest Day
      • The March Charge
      • 7 Bridges Walk
      • Stars Dance for Cancer
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  • Cancer of unknown primary (CUP)
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  • Prognosis
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Prognosis

Prognosis means the expected outcome of a disease. You may wish to discuss your prognosis and treatment options with your doctor, but it is not possible for anyone to predict the exact course of the disease.

To work out your prognosis, your doctor will consider:

  • test results
  • the type of CUP you have
  • where the cancer is located and how far it has spread through the body
  • how fast the cancer is growing
  • how well you respond to treatment
  • the impact the cancer has had on your health factors such as your age, fitness and medical history.

Although most cases of CUP can’t be cured, treatment can keep some cancers under control for months or years. Whatever the prognosis, palliative treatment can relieve symptoms such as pain to improve quality of life. It can be used at any stage of advanced cancer. See more on palliative treatment.

Discussing your prognosis and thinking about the future can be challenging and stressful. It is important to know that although the statistics for CUP can be frightening, they are an average and may not apply to your situation. Talk to your doctor about how to interpret any statistics that you come across.

Staging is a way to describe how far a cancer has spread. CUP cannot be given a stage because the primary cancer is not known and the cancer has already spread to other parts of the body when it is found. This is considered advanced cancer. For more information, see Living with Advanced Cancer and listen to our podcast series, The Thing About Advanced Cancer.

→ READ MORE: Your healthcare team


Key resource

Download a PDF booklet on this topic.

Understanding Cancer of Unknown Primary cover thumbnail
Understanding Cancer of Unknown Primary

Download PDF519kB

More resources

  • PDF Living with Advanced Cancer Download PDF596kB
  • PDF Emotions and Cancer Download PDF643kB
This information was clinically reviewed in September 2024, and was fully reviewed in September 2022. View who reviewed this content.

Prof Chris Karapetis, Network Clinical Director (Cancer Services), Southern Adelaide Local Health Network, Head, Department of Medical Oncology, and Director, Clinical Research in Medical Oncology, Flinders Medical Centre and Flinders University, SA (Clinical review); Dr Amey Aurangabadkar, Radiologist, Illawarra Radiology Group, NSW; Clare Brophy, Consumer; Prof Katherine Clark, Clinical Director of Palliative Care, NSLHD Supportive and Palliative Care Network, Northern Sydney Cancer Centre, Royal North Shore Hospital, NSW; Prof Wendy Cooper, Senior Staff Specialist, Tissue Pathology and Diagnostic Oncology, NSW Health Pathology, Royal Prince Alfred Hospital, NSW; A/Prof Richard Gallagher, Head and Neck Surgeon, Director of Cancer Services and Head and Neck Cancer Services, St Vincent’s Health Network, NSW; Dr Chloe Georgiou, Oncology Research Fellow, Australian Rare Cancer Portal, and Oncology Trials Fellow, Bendigo Health Cancer Centre, VIC; Dr Susan Harden, Radiation Oncologist, Peter MacCallum Cancer Centre, VIC; Justin Hargreaves, Medical Oncology Nurse Practitioner, Bendigo Health Cancer Centre, VIC; Dr Laura Kirsten, Principal Clinical Psychologist, Nepean Cancer Care Centre, NSW; Prof Linda Mileshkin, Medical Oncologist, Peter MacCallum Cancer Centre, VIC; Caitriona Nienaber, 13 11 20 Consultant, Cancer Council WA.

View the Cancer Council NSW editorial policy.

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  • Cancer of unknown primary (CUP)
  • About CUP
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