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    • What is cancer?
    • Types of cancer
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      • Blood cancers
      • Breast cancer
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      • Melanoma
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      • View 45 other cancers
    • Coping with a diagnosis
      • Coping with emotions
      • Tests and scans
      • Talking to kids about cancer
      • Cancer and your finances
      • Cancer and work
      • Cancer care and your rights
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      • Treatment options
      • Chemotherapy
      • Radiation therapy
      • Surgery
      • Immunotherapy
      • Targeted therapy
      • Hormone therapy
      • Clinical trials
      • Palliative treatment
    • Managing side effects
      • Fatigue
      • Taste and smell changes
      • Heart health and cancer
      • Hair loss
      • Pain and cancer
      • Peripheral neuropathy
      • Changes in thinking and memory
      • Lymphoedema
      • Mouth health
      • Nutrition and cancer
      • Breast prostheses and reconstruction
      • Fertility
      • Sexuality
    • Supporting someone with cancer
      • Caring for someone with cancer
      • Caring for someone with advanced cancer
      • Family and friends
      • Supportive schools
      • Supportive workplaces
      • Caring for mob with cancer
    • Living well during and after treatment
      • Nutrition and cancer
      • Exercise and cancer
      • Complementary therapies
      • Living well after treatment
    • Advanced cancer
      • Living with advanced cancer
      • Caring for someone with advanced cancer
      • Palliative care
      • Facing end of life
      • Coping with grief
    • Information for your community
      • Aboriginal & Torres Strait Islander peoples
      • Resources in different languages
      • Easy Read resources
      • Resources for LGBTQI+ people
    • Fact sheets, podcasts and more
      • Cancer resource hub – fact sheets, booklets and more
      • Cancer Council Podcasts
  • Get Support
    Our cancer helpline consultants are ready for your call to support all people impacted by cancer. We may be able to assist with direct support services or by putting you in touch with other people who can support you.
    • 13 11 20 – Speak to a cancer professional
    • How can we help you
      • Accommodation during treatment
      • Cancer Counselling
      • Financial Support
      • Legal & Workplace Support
      • Transport to treatment
      • Support after treatment
    • Connect with others
    • Online community
    • Coping with a diagnosis
      • Coping with emotions
      • Talking to kids about cancer
      • Cancer and your finances
      • Cancer and work
      • Cancer care and your rights
    • Health care professionals
    • Cancer stories
    • Cancer podcasts
    • Meditation and relaxation podcasts
  • Preventing Cancer
    Discover lifestyle choices to minimise your risk of getting cancer and the importance of screening and early detection for cancer survival.
    • Healthy diet and exercise
      • Limit alcohol
      • Be a healthy weight
      • Move more, sit less
      • Healthy Made Tasty
      • Our Kids Our Call
    • Quit smoking and vaping
      • Quit smoking
      • Tackling Tobacco
      • Smoke free environments
      • Electronic cigarettes
      • Generation Vape
    • Sun protection
      • Slip on a shirt
      • Slop on sunscreen
      • Slap on a hat
      • Seek shade
      • Slide on sunglasses
      • SunSmart NSW website
      • Improve your long game
      • Outdoor workers
      • Sporting groups
      • Buy sun protection products online
    • Screening and early detection
      • Cervical screening
      • Bowel cancer screening
      • Breast cancer screening
      • Lung cancer screening
      • Testicular cancer
      • Prostate cancer
      • Ovarian cancer
      • Liver cancer and hepatitis B
      • Check for skin cancer
    • CanAct – campaigning for better policies
    • Cancer Council shops
  • Research
    Research programs save lives, improve treatments and quality of life for cancer survivors.
    • Research we conduct
      • The Daffodil Centre
      • I-PaRCS
    • Research we fund
    • Search research by cancer type or topic
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      • Make a major gift
      • Donate crypto
      • More ways to donate
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      • Events calendar
      • Fundraise your way – Do It For Cancer
      • Australia’s Biggest Morning Tea
      • Daffodil Day
      • Relay for Life
      • The Longest Day
      • The March Charge
      • 7 Bridges Walk
      • Stars Dance for Cancer
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  • Predicting responses to cancer immunotherapy

Predicting responses to cancer immunotherapy

University of Sydney 2018-2020

Background

Immune therapies based on ‘checkpoint inhibitors’ have provided new hope for patients with previously incurable melanomas and lung cancers. Checkpoint inhibitors are drugs that enable the patient’s immune cells to eliminate cancers by blocking immune ‘off switches’. Up to 40% of patients with advanced melanoma and over 20% of patients with advanced lung cancer can be cured with these new treatments. But they don’t work for some patients. Since they are costly and can produce life-threatening side effects, a way of predicting which patients will benefit from treatment is urgently needed.

The research

Professor Fazekas is using technology called mass cytometry to develop a blood test that will predict which patients will respond to immune checkpoint therapy. Her team has identified a large number of different types of immune cells in the blood of cancer patients and previously found that the numbers of many immune cell types were abnormal in patients who later failed to respond. This research will test how accurately each patient’s pattern of abnormal immune cells, or ‘immune signature’, predicts their response to therapy. The team will also try to identify additional signatures for patients with other types of cancer and link these with responses to immune therapies or combinations of immune therapies and chemotherapies.

The impact

Professor Fazekas’ work has potentially major benefits for patient care because it brings the concept of personalised medicine much closer to reality. It should allow informed decisions about which patients should undergo immune checkpoint therapies, reducing the burden of side effects for those that won’t respond and allowing these costly new treatments to be given to only those patients who stand to benefit. Since many different types of immune therapies are in the pipeline for other cancers, her work also has potential to significantly improve cancer care more broadly in future.

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