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    • What is cancer?
    • Types of cancer
      • Bowel cancer
      • Blood cancers
      • Breast cancer
      • Lung cancer
      • Melanoma
      • Prostate cancer
      • View 45 other cancers
    • Coping with a diagnosis
      • Coping with emotions
      • Tests and scans
      • Talking to kids about cancer
      • Cancer and your finances
      • Cancer and work
      • Cancer care and your rights
    • Cancer treatment
      • Treatment options
      • Chemotherapy
      • Radiation therapy
      • Surgery
      • Immunotherapy
      • Targeted therapy
      • Hormone therapy
      • Clinical trials
      • Palliative treatment
    • Managing side effects
      • Fatigue
      • Taste and smell changes
      • Heart health and cancer
      • Hair loss
      • Pain and cancer
      • Peripheral neuropathy
      • Changes in thinking and memory
      • Lymphoedema
      • Mouth health
      • Nutrition and cancer
      • Breast prostheses and reconstruction
      • Fertility
      • Sexuality
    • Supporting someone with cancer
      • Caring for someone with cancer
      • Caring for someone with advanced cancer
      • Family and friends
      • Supportive schools
      • Supportive workplaces
      • Caring for mob with cancer
    • Living well during and after treatment
      • Nutrition and cancer
      • Exercise and cancer
      • Complementary therapies
      • Living well after treatment
    • Advanced cancer
      • Living with advanced cancer
      • Caring for someone with advanced cancer
      • Palliative care
      • Facing end of life
      • Coping with grief
    • Information for your community
      • Aboriginal & Torres Strait Islander peoples
      • Resources in different languages
      • Easy Read resources
      • Resources for LGBTQI+ people
    • Fact sheets, podcasts and more
      • Cancer resource hub – fact sheets, booklets and more
      • Cancer Council Podcasts
  • Get Support
    Our cancer helpline consultants are ready for your call to support all people impacted by cancer. We may be able to assist with direct support services or by putting you in touch with other people who can support you.
    • 13 11 20 – Speak to a cancer professional
    • How can we help you
      • Accommodation during treatment
      • Cancer Counselling
      • Financial Support
      • Legal & Workplace Support
      • Transport to treatment
      • Support after treatment
    • Connect with others
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    • Coping with a diagnosis
      • Coping with emotions
      • Talking to kids about cancer
      • Cancer and your finances
      • Cancer and work
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    • Cancer stories
    • Cancer podcasts
    • Meditation and relaxation podcasts
  • Preventing Cancer
    Discover lifestyle choices to minimise your risk of getting cancer and the importance of screening and early detection for cancer survival.
    • Healthy diet and exercise
      • Limit alcohol
      • Be a healthy weight
      • Move more, sit less
      • Healthy Made Tasty
      • Our Kids Our Call
    • Quit smoking and vaping
      • Quit smoking
      • Tackling Tobacco
      • Smoke free environments
      • Electronic cigarettes
      • Generation Vape
    • Sun protection
      • Slip on a shirt
      • Slop on sunscreen
      • Slap on a hat
      • Seek shade
      • Slide on sunglasses
      • SunSmart NSW website
      • Improve your long game
      • Outdoor workers
      • Sporting groups
      • Buy sun protection products online
    • Screening and early detection
      • Cervical screening
      • Bowel cancer screening
      • Breast cancer screening
      • Lung cancer screening
      • Testicular cancer
      • Prostate cancer
      • Ovarian cancer
      • Liver cancer and hepatitis B
      • Check for skin cancer
    • CanAct – campaigning for better policies
    • Cancer Council shops
  • Research
    Research programs save lives, improve treatments and quality of life for cancer survivors.
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      • Australia’s Biggest Morning Tea
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  • New approaches to aggressive breast cancers

New approaches to aggressive breast cancers

The University of Newcastle 2015–2017

A team of researchers led by Dr Nicole Verrills has been investigating if a new ‘gene marker’ can predict which breast cancer patients may have poorer treatment outcomes. They have also identified a potential new treatment option for these patients.

Background

Breast cancer is the number one cancer affecting Australian women, with around 3,000 people dying from the disease each year. Survival rates have increased dramatically over the last two decades, but the 5-year survival of patients whose breast cancer has metastasised, or spread,
is only 23%.

A big challenge with breast cancer is that it is not just one disease – in fact there are several different subtypes of breast cancer. ‘Luminal B’ breast cancer accounts for around 21% of all breast cancers and is linked to treatment resistance and poor survival. There is no accurate way of identifying which women have this type of breast cancer.

The research

Dr Verrills and her team have discovered a key mechanism that makes some breast cancers more aggressive and resistant to standard treatments. In particular, her research has been exploring the association between the gene PPP2R2A and Luminal B breast cancer. The team has discovered that breast cancer cells become more aggressive when this gene is missing. The cells also become resistant to standard therapies. This suggests patients who have lost this gene will have a worse outcome from their cancer compared to those with an intact PPP2R2A gene.

Importantly, Dr Verrills has discovered that breast cancer cells with this gene marker are sensitive to a drug that is already in clinical use for other diseases. These drugs can not only effectively kill these cells, but can also re-sensitize the tumour to standard treatment. The team is now working towards validating their findings in preclinical testing.

The impact

Dr Verrills and her team are now looking at how testing for the PPP2R2A gene could be used as a diagnostic tool. When a woman is first diagnosed with breast cancer, she could be tested for this gene. If found to be missing the PPP2R2A gene, this would indicate she is likely to be resistant to traditional therapies and needs an alternative treatment.

The team has also found that breast cancers with low PPP2R2A levels could be highly sensitive to a certain type of chemotherapy. If more preclinical testing confirms these results, this chemotherapy could be introduced into clinical trials for patients who have low PPP2R2A levels offering hope for patients with treatment resistant breast cancer.

Research team

Dr Nicole Verrills
The University of Newcastle

Dr Kathryn Skelding

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