- Pancreatic neuroendocrine tumours (NETs)
- Advanced pancreatic NETs
- Peptide receptor radionuclide therapy (PRRT)
Peptide receptor radionuclide therapy (PRRT) for pancreatic NETs
PRRT is a type of internal radiation therapy used to treat advanced pancreatic NETs that have large numbers of somatostatin receptors. These are proteins found on the surface of the tumour.
If you have PRRT, you will be injected with a somatostatin analogue (SSA) that has been combined with a small amount of a radioactive substance (radionuclide). This mixture targets the somatostatin receptors and delivers a high dose of radiation that kills or damages the cancer cells.
You may have a dose of chemotherapy before PRRT to make the cancer cells more sensitive to the radiation. PRRT is available only in certain treatment centres. You will usually see a nuclear medicine specialist and a medical oncologist.
PRRT is given as an outpatient treatment, with a session lasting around 4–5 hours. Depending on the grade of the tumour, you may have four sessions about 6–12 weeks apart. Your doctor will talk to you about possible side effects and safety precautions you may need to follow.
Dr Lorraine Chantrill, Head of Department, Medical Oncology, Illawarra Shoalhaven Local Health District, NSW; Marion Bamblett, Nurse Unit Manager, Cancer Centre, Fiona Stanley Hospital, WA; Prof Katherine Clark, Clinical Director of Palliative Care, Northern Sydney Local Health District Cancer and Palliative Care Network, and Conjoint Professor, Northern Clinical School, The University of Sydney, NSW; Lynda Dunstone, Consumer; Kate Graham, Accredited Practising Dietitian – Upper GI Dietitian, Peter MacCallum Cancer Centre, VIC; Dr Gina Hesselberg, Radiation Oncologist, St George Hospital Cancer Centre, NSW; Dr Marni Nenke, Endocrinologist and Mary Overton Early Career Research Fellow, Royal Adelaide Hospital, SA; Caitriona Nienaber, 13 11 20 Consultant, Cancer Council WA; A/Prof Nicholas O’Rourke, Head of Hepatobiliary Surgery, Royal Brisbane Hospital and The University of Queensland, QLD; Rose Rocca, Senior Clinical Dietitian – Upper GI, Peter MacCallum Cancer Centre, VIC; Gail Smith, Consumer. We also thank the health professionals, consumers and editorial teams who have worked on previous editions of this title.
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